| | City | Population |
| 1. | Panama | 408,168 |
| 2. | San Miguelito | 321,501 |
| 3. | Tocumen | 88,543 |
| 4. | David | 82,859 |
| 5. | Arraijan | 76,815 |
| 6. | Colon | 76,643 |
| 7. | Las Cumbres | 69,102 |
| 8. | La Chorrera | 61,232 |
| 9. | Pacora | 55,530 |
| 10. | Santiago | 45,355 |
| 11. | Chitre | 43,966 |
| 12. | Vista Alegre | 41,786 |
| 13. | Chilibre | 33,536 |
| 14. | Cativa | 29,607 |
| 15. | Nuevo Arraijan | 23,594 |
| 16. | Changuinola | 22,900 |
| 17. | Alcaldediaz | 19,782 |
| 18. | Puerto Armuelles | 18,795 |
| 19. | La Cabima | 17,544 |
| 20. | Aguadulce | 17,237 |
| 21. | La Concepcion | 16,910 |
| 22. | Pedregal | 16,285 |
| 23. | Veracruz | 16,172 |
| 24. | Chepo | 15,335 |
| 25. | Anton | 13,851 |
| 26. | Sabanitas | 12,871 |
| 27. | Penonome | 12,394 |
| 28. | Puerto Escondido | 12,371 |
| 29. | El Coco | 12,124 |
| 30. | Las Lomas | 11,726 |
| 31. | Pocri | 11,447 |
| 32. | Volcan | 11,245 |
| 33. | Bocas del Toro | 9,883 |
| 34. | Ancon | 9,169 |
| 35. | Las Tablas | 8,570 |
| 36. | Guadalupe | 8,408 |
| 37. | Almirante | 8,114 |
| 38. | Sona | 7,400 |
| 39. | Boquete | 6,123 |
| 40. | Guabito | 5,988 |
| 41. | Los Santos | 5,970 |
| 42. | Puerto Pilon | 5,688 |
| 43. | Nata | 5,619 |
| 44. | La Mitra | 4,778 |
| 45. | Rio Hato | 4,752 |
| 46. | El Progreso | 4,292 |
| 47. | Lidice | 4,059 |
| 48. | Potrero Grande | 4,044 |
| 49. | Alto del Espino | 3,672 |
| 50. | Rio Alejandro | 3,632 |
| 51. | Bejuco | 3,420 |
| 52. | Capira | 3,376 |
| 53. | La Herradura | 3,347 |
| 54. | Margarita | 3,302 |
| 55. | Pese | 3,141 |
| 56. | Quebrada Canoa | 3,061 |
| 57. | Buena Vista | 3,060 |
| 58. | Ocu | 2,986 |
| 59. | Canazas | 2,963 |
| 60. | Cerro Punta | 2,957 |
| 61. | Villa Rosario | 2,947 |
| 62. | Parita | 2,875 |
| 63. | Atalaya | 2,856 |
| 64. | Monte Lirio | 2,823 |
| 65. | Gualaca | 2,753 |
| 66. | Paso Blanco | 2,735 |
| 67. | Vista Hermosa | 2,725 |
| 68. | Siogui Abajo | 2,675 |
| 69. | Bugaba | 2,582 |
| 70. | Ustupo | 2,514 |
| 71. | Divala | 2,493 |
| 72. | Chiriqui | 2,431 |
| 73. | Chame | 2,313 |
| 74. | La Pena | 2,274 |
| 75. | Capellania | 2,252 |
| 76. | La Mesa | 2,228 |
| 77. | Chigore | 2,212 |
| 78. | Macaracas | 2,192 |
| 79. | Nuevo Vigia | 2,163 |
| 80. | Progreso | 2,107 |
| 81. | Guarare | 2,104 |
| 82. | Playon Chico | 2,042 |
| 83. | Los Algarrobos | 2,028 |
| 84. | Santa Rita Arriba | 1,960 |
| 85. | Santa Marta | 1,952 |
| 86. | La Esperanza | 1,952 |
| 87. | La Pintada | 1,938 |
| 88. | Rio Sereno | 1,908 |
| 89. | San Francisco | 1,898 |
| 90. | Santo Domingo | 1,876 |
| 91. | Montijo | 1,873 |
| 92. | La Palma | 1,845 |
| 93. | Quebrada Bonita Adentro | 1,807 |
| 94. | Escobal | 1,790 |
| 95. | San Vicente de Bique | 1,784 |
| 96. | Achutupo Numero Dos | 1,753 |
| 97. | Santa Maria | 1,739 |
| 98. | Nuevo Emperador | 1,723 |
| 99. | El Espino | 1,717 |
| 100. | Churuquita Grande | 1,685 |
The Source for World Rankings